N-Methylisobutylamine → 2-(Isobutyl-methyl-amino)-6-methyl-isonicotinic acid

HRID 1908751Notizen

Reaktionsgleichung

[CH3:1][N:2]([CH3:13])[C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([CH3:12])[N:11]=1)[C:6]([OH:8])=[O:7].Cl[C:15]1[CH:16]=[C:17](C=C(C)N=1)C(O)=O.C(NC)C(C)C>>[CH2:1]([N:2]([CH3:13])[C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([CH3:12])[N:11]=1)[C:6]([OH:8])=[O:7])[CH:16]([CH3:17])[CH3:15]

Komponenten

Edukt 3

HCID 12249N-Methylisobutylamine

HCID 1412092-Chloro-6-methylpyridine-4-carboxylic acid

HCID 179213472-(Dimethylamino)-6-methylpyridine-4-carboxylic acid

Produkt 1

HCID 584180962-(Isobutyl-methyl-amino)-6-methyl-isonicotinic acid

Versuchsvorschrift

The title compound is prepared in analogy to 2-dimethylamino-6-methyl-isonicotinic acid starting from 2-chloro-6-methyl-isonicotinic acid and using isobutyl-methyl-amine; LC-MS: tR=0.61 min, [M+H]+=223.10.

Quellen und Nachweise

ORD-Eintrag: ord-003ea23c2ad24a7089b6d50ea4e47337
Quelldatensatz: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08598208B2

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