Nitric Acid → 2-Methyl-3-nitro-5-(trifluoromethyl)benzoic acid

HRID 1909329Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1909329
[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[N+:15]([O-])([OH:17])=[O:16]>OS(O)(=O)=O>[CH3:1][C:2]1[C:10]([N+:15]([O-:17])=[O:16])=[CH:9][C:8]([C:11]([F:12])([F:13])[F:14])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 27755852-Methyl-5-(trifluoromethyl)benzoic acid

Produkt 1

HCID 682955012-Methyl-3-nitro-5-(trifluoromethyl)benzoic acidAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel2×

Versuchsvorschrift

A stirred solution of 2-methyl-5-(trifluoromethyl)benzoic acid (1 mmol) in conc. H2SO4 (2 mL) was cooled to −10° C. and a nitrating mixture (0.4 mL of conc. H2SO4+0.1 mL of conc. HNO3) was added to it in dropwise manner. The reaction mixture was stirred at same temperature for 20 min before warming to room temperature. The resulting precipitate was filtered off and dried to obtain 2-methyl-3-nitro-5-(trifluoromethyl)benzoic acid which was used in next step without further purification (yield 60-70%).

Aufarbeitung

  1. filtrationThe resulting precipitate was filtered off
  2. customdried

Quellen und Nachweise

ORD-Eintrag
ord-3a70af5183e6459fb3acd2a9a00375a4
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08598167B1

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