methyl 2-amino-1H-benzo[d]imidazole-4-carboxylate → 2-amino-6-pyridin-4-yl-1H-benzoimidazole-4-carboxylic acid methyl ester

HRID 1910210

Reaktionsgleichung

Reaktionsgleichung von HRID 1910210
[CH3:1][O:2][C:3]([C:5]1[C:13]2[N:12]=[C:11]([NH2:14])[NH:10][C:9]=2[CH:8]=[CH:7][CH:6]=1)=[O:4].COC(=O)C1C=C([C:24]2[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=2)C=C([N+]([O-])=O)C=1N>>[CH3:1][O:2][C:3]([C:5]1[C:13]2[N:12]=[C:11]([NH2:14])[NH:10][C:9]=2[CH:8]=[C:7]([C:24]2[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=2)[CH:6]=1)=[O:4]

Komponenten

3

Edukt 2

HCID 24730367methyl 2-amino-1H-benzo[d]imidazole-4-carboxylate2×HCID 66940533HCID 66940533, Verbindung

Produkt 1

HCID 669405032-amino-6-pyridin-4-yl-1H-benzoimidazole-4-carboxylic acid methyl esterAusbeute 50 %

Versuchsvorschrift

0.25 g (50% overall yield) of 2-amino-6-pyridin-4-yl-1H-benzoimidazole-4-carboxylic acid methyl ester was synthesized according to procedures described for the synthesis of 2-Amino-1H-benzoimidazole-4-carboxylic acid methyl ester (intermediate A) starting from 0.5 g (1.8 mmol) of above synthesized 2-Amino-3-nitro-5-pyridin-4-yl-benzoic acid methyl ester. LCMS: 269 (M+1)+.

Quellen und Nachweise

ORD-Eintrag
ord-897508facca94758b487c46a4f770df0
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08598353B2

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