Phosphorus oxychloride → 2-Chloro-8-(trifluoromethyl)quinoline
Reaktionsgleichung
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[NH:11][C:10](=O)[CH:9]=[CH:8]2.O=P(Cl)(Cl)[Cl:18]>>[Cl:18][C:10]1[CH:9]=[CH:8][C:7]2[C:12](=[C:3]([C:2]([F:15])([F:14])[F:1])[CH:4]=[CH:5][CH:6]=2)[N:11]=1Komponenten
3
Versuchsvorschrift
8-Trifluoromethyl-1H-quinolin-2-one (8.35 g, 39.2 mmol) was taken in a 25 mL RB POCl3 (10 mL) was added, and then refluxed for 1 h. The excess POCl3 was distilled off and ice was added to the reaction mixture. This was stirred for 15 min, the precipitate was filtered off and then dried under vacuum to afford the title compound (3 g, yield: 33%).
Aufarbeitung
- additionwas added
- temperaturerefluxed for 1 h
- distillationThe excess POCl3 was distilled off
- additionice was added to the reaction mixture
- filtrationthe precipitate was filtered off
- customdried under vacuum
Quellen und Nachweise
- ORD-Eintrag
- ord-ced68df90c104877ac009b731c0b2942
- Quelldatensatz
- uspto-grants-2013_12
- Patentnummer
- US08604055B2
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