Methylamine → 1269615-30-6

HRID 1911844Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1911844
Cl[CH2:2][C:3]1[N:4]=[N:5][N:6]([CH3:8])[N:7]=1.[CH3:9][NH2:10]>>[CH3:9][NH:10][CH2:2][C:3]1[N:4]=[N:5][N:6]([CH3:8])[N:7]=1

Komponenten

3

Edukt 2

HCID 6329MethylamineHCID 122050815-chloromethyl-2-methyl-2H-tetrazole

Produkt 1

HCID 670586961269615-30-6

Reaktionsbedingungen

Temperatur
45 °C

Versuchsvorschrift

To 5-(chloromethyl)-2-methyl-2H-tetrazole (136.8 mg, 1.032 mmol), was added methylamine (4.00 mL of 2M solution in THF, 8.00 mmol). This was stirred for 16 hours at 45° C. A white precipitate formed in the reaction and it was allowed to continue stirring for another 24 hours at room temperature before being concentrated in vacuo and successively azeotroped with THF, triethylamine, methanol, and then DCM. 1H NMR (600 MHz, CDCl3) δ 2.23 (s, 3H), 3.80 (s, 2H), 4.29 (s, 3H).

Aufarbeitung

  1. customA white precipitate formed in the reaction and it
  2. stirringto continue stirring for another 24 hours at room temperature
  3. concentrationbefore being concentrated in vacuo
  4. customsuccessively azeotroped with THF, triethylamine, methanol

Quellen und Nachweise

ORD-Eintrag
ord-0bcd22bebf4d40928a69a85fd30ac9f7
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08604038B2

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