Hydroquinone → Ethyl 3-isobutyl-2-piperidin-1-ylcyclobutanecarboxylate

HRID 1912041Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1912041
[CH3:1][CH:2]([CH3:12])[CH2:3][CH:4]=[CH:5][N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.[C:13]([O:17][CH2:18][CH3:19])(=[O:16])[CH:14]=[CH2:15].C1(C=CC(O)=CC=1)O>C(#N)C>[CH2:3]([CH:4]1[CH2:15][CH:14]([C:13]([O:17][CH2:18][CH3:19])=[O:16])[CH:5]1[N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)[CH:2]([CH3:12])[CH3:1]

Komponenten

5

Edukt 3

HCID 785HydroquinoneHCID 8821Ethyl AcrylateHCID 866750301-(4-Methyl-1-pentenyl)piperidine

Produkt 1

HCID 71114720Ethyl 3-isobutyl-2-piperidin-1-ylcyclobutanecarboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
95 °C

Versuchsvorschrift

1-(4-Methyl-1-pentenyl)piperidine (844 g) and acetonitrile (70 mL) were mixed. The ethyl acrylate (443 mL) and hydroquinone (447 mg) were added to the mixture. The resulting mixture was stirred at 95° C. overnight. The reaction mixture was concentrated in vacuo to give the title compound (994.08 g) as a crude product.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5f2b1b1c37084f429c24b4bafa910bcc
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08604069B2

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