1,4-Dioxane hydrochloride → 3,3-Difluoro-1,6-diaza-spiro[3.5]nonane-1-carboxylic acid benzyl ester
Reaktionsgleichung
C(OC([N:8]1[CH2:28][CH2:27][CH2:26][C:10]2([N:13]([C:14]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:15])[CH2:12][C:11]2([F:25])[F:24])[CH2:9]1)=O)(C)(C)C.Cl.O1CCOCC1>>[CH2:17]([O:16][C:14]([N:13]1[C:10]2([CH2:26][CH2:27][CH2:28][NH:8][CH2:9]2)[C:11]([F:25])([F:24])[CH2:12]1)=[O:15])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1Komponenten
3
Versuchsvorschrift
To an optically-active compound of 3,3-difluoro-1,6-diaza-spiro[3.5]nonane-1,6-dicarboxylic acid 1-benzyl ester 6-tert-butyl ester (12.6 g) was added 4M hydrochloric acid-1,4-dioxane (126 ml), and the mixture was stirred at room temperature for 30 minutes. The mixture was concentrated under reduced pressure, and thereto was added toluene. The mixture was concentrated under reduced pressure again to give the titled compound (11.2 g).