Thionyl Chloride → HCID 86665150, Verbindung

HRID 1912510Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1912510
[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10](O)=[O:11].S(Cl)([Cl:16])=O>CN(C)C=O>[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10]([Cl:16])=[O:11]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 671611162-((1S,2S,5S)-6,6-Dimethylbicyclo[3.1.1]heptan-2-yl)acetic acid

Produkt 1

HCID 86665150HCID 86665150, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
22 °C

Versuchsvorschrift

To a mixture of Example 1B (300 mg, 1.65 mmol) and thionyl chloride (901 μL, 12.4 mmol) was added a drop of dimethylformamide. The reaction was stirred at about 22° C. for 2 hours. The excess thionyl chloride was evaporated and the residue was dried under vacuum to afford the title compound.

Aufarbeitung

  1. customThe excess thionyl chloride was evaporated
  2. customthe residue was dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-4406a30cc25e48f1883537dfb684f406
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08609674B2

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