2-Methoxyethyl chloroformate → (1-{4-[3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido]phenyl}-1H-benzimidazol-5-yl)carbamic acid 2-methoxyethyl ester
Reaktionsgleichung
Cl.[NH2:2][C:3]1[CH:32]=[CH:31][C:6]2[N:7]([C:10]3[CH:15]=[CH:14][C:13]([NH:16][C:17]([NH:19][C:20]4[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([C:27]([F:30])([F:29])[F:28])[CH:21]=4)=[O:18])=[CH:12][CH:11]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1.Cl[C:34]([O:36][CH2:37][CH2:38][O:39][CH3:40])=[O:35]>>[CH3:40][O:39][CH2:38][CH2:37][O:36][C:34](=[O:35])[NH:2][C:3]1[CH:32]=[CH:31][C:6]2[N:7]([C:10]3[CH:15]=[CH:14][C:13]([NH:16][C:17]([NH:19][C:20]4[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([C:27]([F:29])([F:30])[F:28])[CH:21]=4)=[O:18])=[CH:12][CH:11]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1Komponenten
3
Versuchsvorschrift
The title compound can be synthesized from 1-[4-(5-aminobenzimdazol-1-yl)phenyl]-3-(4-chloro-3-(trifluoro-methyl)phenyl)urea hydrochloride and methoxyethyl chloroformate by the same method as in Example 41.
Quellen und Nachweise
- ORD-Eintrag
- ord-fc4bac64938244a6a399690792b4fc4c
- Quelldatensatz
- uspto-grants-2013_12
- DOI