Thionyl Chloride → HCID 86665150, Verbindung

HRID 1912894Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1912894
[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10](O)=[O:11].S(Cl)([Cl:16])=O>CN(C)C=O>[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10]([Cl:16])=[O:11]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 671611162-((1S,2S,5S)-6,6-Dimethylbicyclo[3.1.1]heptan-2-yl)acetic acid

Produkt 1

HCID 86665150HCID 86665150, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
22 °C

Versuchsvorschrift

To a mixture of the product from Example 4B (300 mg, 1.65 mmol) and thionyl chloride (901 μL, 12.4 mmol) was added a drop of dimethylformamide. The reaction was stirred at 22° C. for 2 hours. The excess of thionyl chloride was evaporated and the residue was dried under vacuum to afford the title compound.

Aufarbeitung

  1. customThe excess of thionyl chloride was evaporated
  2. customthe residue was dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-725e7c30827546548599d3f286001c5d
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08609669B2

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