Thionyl Chloride → HCID 86665181, Verbindung

HRID 1912947Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1912947
[CH:1]1([S:6][CH2:7][C:8]([OH:10])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:13])=O>>[CH:1]1([S:6][CH2:7][C:8]([Cl:13])=[O:10])[CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 15728315(Cyclopentylsulfanyl)acetic acid

Produkt 1

HCID 86665181HCID 86665181, Verbindung

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

The product from Example 143B (6.56 g) was combined with thionyl chloride (50 mL, 685 mmol) and the reaction mixture was heated at 70° C. for 2 hours. The reaction mixture was concentrated under vacuum, and the residue was dissolved in CHCl3 (50 mL) and concentrated again to remove excess thionyl chloride. The residue was distilled under vacuum (air bath 100-110° C./˜10 mm) to provide the title compound, used directly for the next step.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. dissolutionthe residue was dissolved in CHCl3 (50 mL)
  3. concentrationconcentrated again
  4. customto remove excess thionyl chloride
  5. distillationThe residue was distilled under vacuum (air bath 100-110° C./˜10 mm)

Quellen und Nachweise

ORD-Eintrag
ord-ba22d4f86d254542b5d9526c68ae0697
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08609669B2

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