3,4-Diaminopyridine → biphenyl-4-yl[4-(1H-imidazo[4,5-c]pyridin-2-yl)piperidin-1-yl]methanone

https://huagongshe.com/reaction/1913159

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	3,4-Diaminopyridine	HCID 5918	—
Edukt	Triphenyl Phosphate	HCID 8289	—
Edukt	1-([1,1'-Biphenyl]-4-carbonyl)piperidine-4-carboxylic acid	HCID 893053	—
Lösungsmittel	Pyridine	HCID 1049	—
Produkt	biphenyl-4-yl[4-(1H-imidazo[4,5-c]pyridin-2-yl)piperidin-1-yl]methanone	HCID 178519408	27,8%

Reaktionsbedingungen

Temperatur	120 °C

Reaktionsschritte

To a mixture of 1-(biphenyl-4-ylcarbonyl)piperidine-4-carboxylic acid (0.10 g, 0.32 mmol) and 3,4-diaminopyridine (35 mg, 0.32 mmol) in pyridine (1 mL) is added triphenyl phosphate (0.10 mL, 0.38 mmol). The mixture is heated under microwave irradiation at 120° C. for 50 mins. Purification by preparative HPLC gives 34 mg of biphenyl-4-yl[4-(1H-imidazo[4,5-c]pyridin-2-yl)piperidin-1-yl]methanone.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08609696B2
Quelldatensatz	uspto-grants-2013_12
ORD ID	ord-372b6ab6863c4d32aaf284a40ee14b9c
Quellennotiz	uspto-grants-2013_12