Hydrochloric Acid → 4-CarboxyMethyl-cyclohexanecarboxylic acid ethyl ester

HRID 1913213Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1913213
C([O:5][C:6](=[O:19])[CH2:7][CH:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]1)(C)(C)C.Cl>O1CCOCC1>[CH2:17]([O:16][C:14]([CH:11]1[CH2:12][CH2:13][CH:8]([CH2:7][C:6]([OH:19])=[O:5])[CH2:9][CH2:10]1)=[O:15])[CH3:18]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 66613615Ethyl 4-(2-tert-butoxy-2-oxoethyl)cyclohexanecarboxylate

Produkt 1

HCID 158961924-CarboxyMethyl-cyclohexanecarboxylic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a 100 mL round-bottom flask was charged ethyl 4-(2-tert-butoxy-2-oxoethyl)cyclohexanecarboxylate (Int-4b, 2.00 g, 7.40 mmol) and 4N HCl in 1,4-dioxane. The resulting solution was stirred at room temperature for 2 hours. At this point the solvent was removed in vacuo and the resulting residue was diluted with DCM and washed with H2O. The organic layer was dried over Na2SO4 and reduced in vacuo. The resulting residue was taken on without further purification.

Aufarbeitung

  1. customAt this point the solvent was removed in vacuo
  2. additionthe resulting residue was diluted with DCM
  3. washwashed with H2O
  4. dry with materialThe organic layer was dried over Na2SO4
  5. customThe resulting residue was taken on without further purification

Quellen und Nachweise

ORD-Eintrag
ord-11b5d88ef7354042b7aaa5721929ff84
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08609675B2

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