HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-t-Butylbenzenesulfonyl chloride → 2-{1-[(4-tert-Butylphenyl)sulfonyl]piperidin-4-yl}-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-t-Butylbenzenesulfonyl chloride | HCID 139882 | — |
| Edukt | 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride | HCID 66616406 | — |
| Produkt | 2-{1-[(4-tert-Butylphenyl)sulfonyl]piperidin-4-yl}-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one | HCID 46202062 | — |
Reaktionsschritte
The title compound is prepared analogously as described for GP1 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one hydrochloride (compound B1*HCl) and 4-tert-butylbenzenesulfonyl chloride as starting compounds. The crude product is purified by crystallization from methanol to yield the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08609848B2 |
| Quelldatensatz | uspto-grants-2013_12 |
| ORD ID | ord-22d2dbd6608b4f44a872f20039f7e350 |
| Quellennotiz | uspto-grants-2013_12 |