3-Methylbenzenesulphonyl chloride → 5-[3-(Cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-4,4-dimethyl-2-{1-[(3-methylphenyl)sulfonyl]piperidin-4-yl}-2,4-dihydro-3H-pyrazol-3-one

HRID 1914169Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1914169
Cl.[CH:2]1([CH2:5][O:6][C:7]2[CH:8]=[C:9]([C:17]3[C:18]([CH3:30])([CH3:29])[C:19](=[O:28])[N:20]([CH:22]4[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]4)[N:21]=3)[CH:10]=[CH:11][C:12]=2[O:13][CH:14]([F:16])[F:15])[CH2:4][CH2:3]1.[CH3:31][C:32]1[CH:33]=[C:34]([S:38](Cl)(=[O:40])=[O:39])[CH:35]=[CH:36][CH:37]=1>>[CH:2]1([CH2:5][O:6][C:7]2[CH:8]=[C:9]([C:17]3[C:18]([CH3:30])([CH3:29])[C:19](=[O:28])[N:20]([CH:22]4[CH2:27][CH2:26][N:25]([S:38]([C:34]5[CH:35]=[CH:36][CH:37]=[C:32]([CH3:31])[CH:33]=5)(=[O:40])=[O:39])[CH2:24][CH2:23]4)[N:21]=3)[CH:10]=[CH:11][C:12]=2[O:13][CH:14]([F:15])[F:16])[CH2:3][CH2:4]1

Komponenten

3

Edukt 2

HCID 27345953-Methylbenzenesulphonyl chlorideHCID 666165795-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride2×

Produkt 1

HCID 673851985-[3-(Cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-4,4-dimethyl-2-{1-[(3-methylphenyl)sulfonyl]piperidin-4-yl}-2,4-dihydro-3H-pyrazol-3-one

Versuchsvorschrift

The title compound is prepared analogously as described for GP1 using 5-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride (compound B3*HCl) and 3-methylbenzenesulfonyl chloride as starting compounds. The crude product is purified by crystallization from methanol to yield the title compound.

Aufarbeitung

  1. customThe title compound is prepared analogously
  2. customThe crude product is purified by crystallization from methanol

Quellen und Nachweise

ORD-Eintrag
ord-7e3b76b7800142b88ff39a8e36ca9728
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08609848B2

Notizen zur Reaktion

Wird geladen…