5-(Benzyloxy)-2-methylbenzoic acid → 5-[3-(Benzyloxy)-4-methoxyphenyl]-2-(1-{[5-(benzyloxy)-2-methylphenyl]carbonyl}piperidin-4-yl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one
Reaktionsgleichung
Cl.[CH2:2]([O:9][C:10]1[CH:11]=[C:12]([C:18]2[C:19]([CH3:31])([CH3:30])[C:20](=[O:29])[N:21]([CH:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[N:22]=2)[CH:13]=[CH:14][C:15]=1[O:16][CH3:17])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:32]([O:39][C:40]1[CH:41]=[CH:42][C:43]([CH3:49])=[C:44]([CH:48]=1)[C:45](O)=[O:46])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[CH2:2]([O:9][C:10]1[CH:11]=[C:12]([C:18]2[C:19]([CH3:31])([CH3:30])[C:20](=[O:29])[N:21]([CH:23]3[CH2:24][CH2:25][N:26]([C:45]([C:44]4[CH:48]=[C:40]([O:39][CH2:32][C:33]5[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=5)[CH:41]=[CH:42][C:43]=4[CH3:49])=[O:46])[CH2:27][CH2:28]3)[N:22]=2)[CH:13]=[CH:14][C:15]=1[O:16][CH3:17])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The title compound is prepared analogously as described for GP2-WU2 using 5-[3-(benzyloxy)-4-methoxyphenyl]-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one hydrochloride (compound B4*HCl) and 5-(benzyloxy)-2-methylbenzoic acid (compound F1) as starting compounds. The crude product is purified by chromatography (amino phase silica gel and DCM) to yield the title compound.
Aufarbeitung
- customThe title compound is prepared analogously
- customThe crude product is purified by chromatography (amino phase silica gel and DCM)
Quellen und Nachweise
- ORD-Eintrag
- ord-8ab1ea772d5a43df8aca20a15d72bf8f
- Quelldatensatz
- uspto-grants-2013_12
- Patentnummer
- US08609848B2
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