Sodium Hydroxide → 5-(1-methyl-1H-pyrazol-5-yl)-3-thiophenecarboxylic acid

HRID 1914562Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1914562
C[O:2][C:3]([C:5]1[CH:9]=[C:8]([C:10]2[N:11]([CH3:15])[N:12]=[CH:13][CH:14]=2)[S:7][CH:6]=1)=[O:4].[OH-].[Na+]>CO>[CH3:15][N:11]1[C:10]([C:8]2[S:7][CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:9]=2)=[CH:14][CH:13]=[N:12]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 581103165-(2-methyl-2H-pyrazol-3-yl)-thiophene-3-carboxylic acid methyl ester

Produkt 1

HCID 581103265-(1-methyl-1H-pyrazol-5-yl)-3-thiophenecarboxylic acidAusbeute 55 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

5-(2-Methyl-2H-pyrazol-3-yl)-thiophene-3-carboxylic acid methyl ester (0.163 g, 073 mmol) was suspended in methanol (1 mL) then sodium hydroxide (1 M, 0.95 mL) was added and the mixture stirred for 2 hours. The solution was evaporated, the residue was taken up in HCl (1 N, 1.5 mL) and the resultant precipitate was collected by filtration and dried in vacuo to afford the title compound as a white solid (0.084 g). LCMS m/z 209.15 [M+H]+ R.T.=2.76 min (Analytical Method 6).

Aufarbeitung

  1. customThe solution was evaporated
  2. filtrationthe resultant precipitate was collected by filtration
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-54045314cd6d47c2887eb4417b4a24a3
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08614209B2

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