8-[(3-Methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]decane → 3-(1H-imidazol-2-yl)-2-(1H-imidazol-2-ylmethyl)-1-[4-({8-[(3-methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)phenyl]propan-1-one

HRID 1915117Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1915117
[CH3:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH2:7][N:8]1[CH2:17][CH2:16][C:11]2([CH2:15][NH:14][CH2:13][CH2:12]2)[CH2:10][CH2:9]1.[NH:18]1[CH:22]=[CH:21][N:20]=[C:19]1[CH2:23][CH:24]([CH2:35][C:36]1[NH:37][CH:38]=[CH:39][N:40]=1)[C:25]([C:27]1[CH:34]=[CH:33][C:30]([CH:31]=O)=[CH:29][CH:28]=1)=[O:26]>>[NH:18]1[CH:22]=[CH:21][N:20]=[C:19]1[CH2:23][CH:24]([CH2:35][C:36]1[NH:37][CH:38]=[CH:39][N:40]=1)[C:25]([C:27]1[CH:28]=[CH:29][C:30]([CH2:31][N:14]2[CH2:13][CH2:12][C:11]3([CH2:10][CH2:9][N:8]([CH2:7][C:3]4[S:4][CH:5]=[CH:6][C:2]=4[CH3:1])[CH2:17][CH2:16]3)[CH2:15]2)=[CH:33][CH:34]=1)=[O:26]

Komponenten

3

Edukt 2

HCID 689590078-[(3-Methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]decaneHCID 866301014-[3-(1H-imidazol-2-yl)-2-(1H-imidazol-2-ylmethyl)propanoyl]benzaldehyde

Produkt 1

HCID 576855293-(1H-imidazol-2-yl)-2-(1H-imidazol-2-ylmethyl)-1-[4-({8-[(3-methyl-2-thienyl)methyl]-2,8-diazaspiro[4.5]dec-2-yl}methyl)phenyl]propan-1-oneAusbeute 14,7 %

Versuchsvorschrift

Using the compound (64 mg) produced in Example 13 and the compound (54 mg) produced in Example 11, the same operation as in Example 12 was performed. The resulting residue was purified by silica gel chromatography (ethyl acetate:methanol:28% aqueous ammonia=100:10:2) to obtain the title compound (14 mg) having the following physical properties.

Aufarbeitung

  1. customThe resulting residue was purified by silica gel chromatography (ethyl acetate:methanol:28% aqueous ammonia=100:10:2)

Quellen und Nachweise

ORD-Eintrag
ord-ff2d94ca3abd4d68b8a3fc67ac8e63b5
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08614323B2

Notizen zur Reaktion

Wird geladen…