8-Cyclohexyl-2,8-diazaspiro[4.5]decane → 8-cyclohexyl-2-(4-{3-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-2-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methyl]propoxy}benzoyl)-2,8-diazaspiro[4.5]decane

HRID 1915125Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1915125
[CH3:1][Si:2]([CH3:40])([CH3:39])[CH2:3][CH2:4][O:5][CH2:6][N:7]1[CH:11]=[CH:10][N:9]=[C:8]1[CH2:12][CH:13]([CH2:25][C:26]1[N:27]([CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:38])([CH3:37])[CH3:36])[CH:28]=[CH:29][N:30]=1)[CH2:14][O:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][CH:17]=1.[CH:41]1([N:47]2[CH2:56][CH2:55][C:50]3([CH2:54][NH:53][CH2:52][CH2:51]3)[CH2:49][CH2:48]2)[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]1>>[CH:41]1([N:47]2[CH2:48][CH2:49][C:50]3([CH2:54][N:53]([C:20](=[O:21])[C:19]4[CH:23]=[CH:24][C:16]([O:15][CH2:14][CH:13]([CH2:12][C:8]5[N:7]([CH2:6][O:5][CH2:4][CH2:3][Si:2]([CH3:1])([CH3:39])[CH3:40])[CH:11]=[CH:10][N:9]=5)[CH2:25][C:26]5[N:27]([CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:38])([CH3:37])[CH3:36])[CH:28]=[CH:29][N:30]=5)=[CH:17][CH:18]=4)[CH2:52][CH2:51]3)[CH2:55][CH2:56]2)[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]1

Komponenten

3

Edukt 2

HCID 675006728-Cyclohexyl-2,8-diazaspiro[4.5]decaneHCID 689584194-{3-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-2-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methyl]propoxy}benzoic Acid

Produkt 1

HCID 689528438-cyclohexyl-2-(4-{3-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-2-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methyl]propoxy}benzoyl)-2,8-diazaspiro[4.5]decaneAusbeute 80,1 %

Versuchsvorschrift

Except for using the compound (50 mg) produced in Example 103 in place of the compound produced in Example 68 and using 8-cyclohexyl-2,8-diazaspiro[4.5]decane (38 mg) in place of the compound produced in Example 91, the same operation as in Example 92 was performed to obtain the title compound (54 mg) having the following physical properties.

Quellen und Nachweise

ORD-Eintrag
ord-746e36ebdea54bd69c99c4313ecebcea
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08614323B2

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