1-methyl-4-nitro-1H-pyrazole → 8-(2-Methyl-4-nitro-pyrazol-3-yl)-1,4-dioxaspiro[4.5]decan-8-ol

HRID 1915836Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1915836
[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-:9])=[O:8])[CH:4]=[N:3]1.[CH2:10]1[O:20][C:13]2([CH2:18][CH2:17][C:16](=[O:19])[CH2:15][CH2:14]2)[O:12][CH2:11]1>>[CH3:1][N:2]1[C:6]([C:16]2([OH:19])[CH2:17][CH2:18][C:13]3([O:20][CH2:10][CH2:11][O:12]3)[CH2:14][CH2:15]2)=[C:5]([N+:7]([O-:9])=[O:8])[CH:4]=[N:3]1

Komponenten

3

Edukt 2

HCID 198951-methyl-4-nitro-1H-pyrazoleHCID 5674151,4-Dioxaspiro[4.5]decan-8-one

Produkt 1

HCID 866800488-(2-Methyl-4-nitro-pyrazol-3-yl)-1,4-dioxaspiro[4.5]decan-8-olAusbeute 83 %

Versuchsvorschrift

Following the procedure for Intermediate 218 starting from 1-methyl-4-nitro-1H-pyrazole and 1,4-cyclohexanedione monoethylene acetal gave 8-(2-methyl-4-nitro-pyrazol-3-yl)-1,4-dioxaspiro[4.5]decan-8-ol as a light beige solid (3.68 g, 83%). 1H NMR (400 MHz, CDCl3) δ 8.06 (s, 1H), 4.45 (s, 1H), 4.12 (s, 3H), 4.04-3.93 (m, 4H), 2.44-2.34 (m, 2H), 2.23-1.95 (m, 4H), 1.75-1.67 (m, 2H).

Quellen und Nachweise

ORD-Eintrag
ord-9a322281857a4ca0b6c8a888de424e37
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08614206B2

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