Triethylamine → HCID 68407751, Verbindung

HRID 1916022Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1916022
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5](Cl)=[O:6].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2([F:25])[CH2:23][CH:22]2[NH2:24])=[CH:17][CH:16]=1.C(N(CC)CC)C>ClCCl>[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([C@@:21]2([F:25])[CH2:23][C@H:22]2[NH:24][C:5](=[O:6])[C:4]2[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=2[C:2]([F:13])([F:12])[F:1])=[CH:19][CH:20]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 675612-(Trifluoromethyl)benzoyl chlorideHCID 44398212HCID 44398212, Verbindung

Produkt 1

HCID 68407751HCID 68407751, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A solution of 2-trifluoromethylbenzoyl chloride (0.10 g; 0.54 mmol) in dichloromethane (2 ml) added dropwise to a stirred solution of the amine from example P5 (compound Z1.004; 2-(4-chlorophenyl)-2-fluoro-cyclopropylamine; 0.100 g; 0.54 mmol) and triethylamine (0.15 ml; 1.08 m) in dichloromethane (3 ml). Stirred for 1 hr at room temperature then allowed to stand for 18 hr. The white precipitate was filtered off, washed with 2M HCl, saturated NaHCO3 and water and air dried giving the pure cis isomer. 0.065 g (34%).

Aufarbeitung

  1. waitto stand for 18 hr
  2. filtrationThe white precipitate was filtered off
  3. washwashed with 2M HCl, saturated NaHCO3 and water and air
  4. customdried
  5. customgiving the pure cis isomer

Quellen und Nachweise

ORD-Eintrag
ord-f70d5a8add9d40ffa81ceb8eb089972e
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08618023B2

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