Trifluoroacetic acid → 2-[(Azetidin-3-yl)oxy]pyridine
Reaktionsgleichung
F[C:2](F)(F)[C:3]([OH:5])=O.O[CH:9]1[CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]1>>[NH:11]1[CH2:10][CH:9]([O:5][C:3]2[CH:2]=[CH:12][CH:9]=[CH:10][N:11]=2)[CH2:12]1Komponenten
3
Versuchsvorschrift
Preparation of compound P21. Compound P21 was prepared by deprotection of C73 with trifluoroacetic acid as described for t-butyl 3-hydroxyazetidine-1-carboxylate in the preparation of C19 in Example 3, before being used in the coupling step.
Aufarbeitung
- customPreparation of compound P21
Quellen und Nachweise
- ORD-Eintrag
- ord-083566004f204507a4e0c79e0523bcf1
- Quelldatensatz
- uspto-grants-2013_12
- Patentnummer
- US08618117B2
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