Potassium Carbonate → 6-Bromo-2-pyrrolidin-1-ylmethyl-quinoline

HRID 1916628

Reaktionsgleichung

Reaktionsgleichung von HRID 1916628
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH2:12]Br)[CH:6]=[CH:5]2.[NH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1.C([O-])([O-])=O.[K+].[K+]>C(#N)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH2:12][N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)[CH:6]=[CH:5]2

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 589705326-Bromo-2-(bromomethyl)quinoline

Produkt 1

HCID 673647966-Bromo-2-pyrrolidin-1-ylmethyl-quinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

4.60 g (15.28 mmol) 6-bromo-2-bromomethyl-quinoline are added to a solution of 1.40 mL (16.8 mmol) pyrrolidine and 6.34 g (45.9 mmol) K2CO3 in 50 mL acetonitrile. The reaction is stirred overnight at RT and then the inorganic salts are filtered off. The organic phase is washed with water and the aqueous phase is extracted with EtOAc. The combined organic extracts are dried over MgSO4 and the solvent is eliminated i.vac.

Aufarbeitung

  1. filtrationthe inorganic salts are filtered off
  2. washThe organic phase is washed with water
  3. extractionthe aqueous phase is extracted with EtOAc
  4. dry with materialThe combined organic extracts are dried over MgSO4

Quellen und Nachweise

ORD-Eintrag
ord-e81953fcf971414f8406f0421b472477
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08618132B2

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