2-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acid → 2-Pyridin-4-yl-thiazole-4-carboxylic acid [2-methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenyl]-amide

HRID 1916930Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1916930
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:19].[N:20]1[CH:25]=[CH:24][C:23]([C:26]2[S:27][CH:28]=[C:29]([C:31](O)=[O:32])[N:30]=2)=[CH:22][CH:21]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:19][C:31]([C:29]1[N:30]=[C:26]([C:23]2[CH:24]=[CH:25][N:20]=[CH:21][CH:22]=2)[S:27][CH:28]=1)=[O:32]

Komponenten

3

Edukt 2

HCID 7160912-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acidHCID 594018302-Methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenylamine

Produkt 1

HCID 594018012-Pyridin-4-yl-thiazole-4-carboxylic acid [2-methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenyl]-amide

Versuchsvorschrift

The title compound was prepared in a manner substantially the same as example 1 by coupling 2-methyl-4-(2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-phenylamine with 2-pyridin-4-yl-thiazole-4-carboxylic acid. MS: 448.2 (M+H).

Quellen und Nachweise

ORD-Eintrag
ord-223beb740f9540759d0ab24396fe30d5
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08618159B2

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