Acetyl chloride → N-(2-(4-methoxyphenylthio)ethyl)acetamide

HRID 1917066Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1917066
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10][CH2:11][CH2:12][NH2:13])=[CH:6][CH:5]=1.[C:14](Cl)(=[O:16])[CH3:15].C(N(CC)CC)C>C(Cl)Cl>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10][CH2:11][CH2:12][NH:13][C:14](=[O:16])[CH3:15])=[CH:6][CH:5]=1

Komponenten

5

Edukt 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 122619332-(4-Methoxyphenylthio)ethanamine hydrochloride

Produkt 1

HCID 49865266N-(2-(4-methoxyphenylthio)ethyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a solution of compound 1-HCl (0.44 g) in CH2Cl2 (15 mL) cooled to ˜0° C. was added acetyl chloride (1.0 mL) and triethylamine (1.0 mL). The reaction mixture was stirred for 1 hour at 0° C. and washed with 1N HCl, sat. NaHCO3. The solvents were removed by evaporation under reduced pressure to give product 10 as solid (pure by TLC and NMR). Yield: 0.5 g.

Aufarbeitung

  1. washwashed with 1N HCl, sat. NaHCO3
  2. customThe solvents were removed by evaporation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9e9f51fbe6684a45be1b76f13041ff09
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08618282B2

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