Malic Acid → Sunitinib Malate

HRID 1918244

Reaktionsgleichung

Reaktionsgleichung von HRID 1918244
[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[C:30]([OH:38])(=[O:37])[CH:31]([CH2:33][C:34]([OH:36])=[O:35])[OH:32].C1(C)C=CC=CC=1>CN1CCCC1=O>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[CH2:33]([C:34]([OH:36])=[O:35])[C@H:31]([OH:32])[C:30]([OH:38])=[O:37]

Komponenten

5

Edukt 3

HCID 525Malic AcidHCID 1140TolueneHCID 5329102Sunitinib

Produkt 1

HCID 6456015Sunitinib Malate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

1 g of sunitinib base was dissolved in 3 ml of N-methyl pyrrolidone, at RT 0.336 g of Malic acid added (as a solid): the solution was heated to 40° C. than 15 ml of toluene was added and precipitation was observed. The suspension was kept at 40° C. for 1 hour than cooled to 0° C., filtered and washed with toluene. Dried at 60° C. under vacuum for 16 h.

Aufarbeitung

  1. additionadded (as a solid): the solution
  2. additionwas added
  3. customprecipitation
  4. filtrationfiltered
  5. washwashed with toluene
  6. customDried at 60° C. under vacuum for 16 h.

Quellen und Nachweise

ORD-Eintrag
ord-37ec831ba5254c55a2c895c3466e369c
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08618309B2

Verknüpfte Notizen

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