Malic Acid → Sunitinib Malate

HRID 1918245

Reaktionsgleichung

Reaktionsgleichung von HRID 1918245
[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[C:30]([OH:38])(=[O:37])[CH:31]([CH2:33][C:34]([OH:36])=[O:35])[OH:32].C(O)CC>CN1C(=O)CCC1>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[CH2:33]([C:34]([OH:36])=[O:35])[C@H:31]([OH:32])[C:30]([OH:38])=[O:37]

Komponenten

5

Edukt 3

HCID 525Malic AcidHCID 10311-PropanolHCID 5329102Sunitinib

Produkt 1

HCID 6456015Sunitinib Malate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Versuchsvorschrift

2 g of sunitinib base were suspended in 6 ml of NMP under stirring at RT. 0.673 g of Malic acid were added to the mixture and the temperature was set at 40° C. 40 ml n-propanol were dropped in 30 minutes, the suspension was cooled to 0° C., filtered and washed with 10 ml n-propanol. Dried at 70° C. under vacuum for 16 h.

Aufarbeitung

  1. customwas set at 40° C
  2. temperaturethe suspension was cooled to 0° C.
  3. filtrationfiltered
  4. washwashed with 10 ml n-propanol
  5. customDried at 70° C. under vacuum for 16 h.

Quellen und Nachweise

ORD-Eintrag
ord-3999f844e5a14739bf783d924cfdb0e2
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08618309B2

Verknüpfte Notizen

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