Ethanol hydrochloride → 3-[4-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-2-propylphenyloxy]butyl]-1,5,5-trimethylimidazolidine-2,4-dione

HRID 1919765Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1919765
Cl.C(O)C.[F:5][C:6]([F:41])([F:40])[C:7]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][N:27]2[C:31](=[O:32])[C:30]([CH3:34])([CH3:33])[N:29]([CH3:35])[C:28]2=[O:36])=[C:18]([CH2:37][CH2:38][CH3:39])[CH:17]=1)([O:12]COC)[C:8]([F:11])([F:10])[F:9]>>[F:41][C:6]([F:5])([F:40])[C:7]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][N:27]2[C:31](=[O:32])[C:30]([CH3:33])([CH3:34])[N:29]([CH3:35])[C:28]2=[O:36])=[C:18]([CH2:37][CH2:38][CH3:39])[CH:17]=1)([OH:12])[C:8]([F:11])([F:10])[F:9]

Komponenten

3

Edukt 2

HCID 21887872Ethanol hydrochlorideHCID 249910743-[4-[4-[1,1,1,3,3,3-Hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenyloxy]butyl]-1,5,5-trimethylimidazolidine-2,4-dione

Produkt 1

HCID 249910753-[4-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-2-propylphenyloxy]butyl]-1,5,5-trimethylimidazolidine-2,4-dioneAusbeute 82 %

Versuchsvorschrift

Hydrochloric acid-ethanol (2 mol/L, 2 mL) was added to 3-[4-[4-[1,1,1,3,3,3-hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenyloxy]butyl]-1,5,5-trimethylimidazolidine-2,4-dione (55.7 mg, 0.11 mmol), followed by stirring at room temperature for one hour. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by silica gel preparative thin-layer chromatography (hexane:ethyl acetate=2:1) to obtain 41.8 mg of the title compound (yield: 82%) as a colorless crystalline powder.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe resulting residue was purified by silica gel preparative thin-layer chromatography (hexane:ethyl acetate=2:1)

Quellen und Nachweise

ORD-Eintrag
ord-a48bdc306b234139afa9579015d3ee0b
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08168666B2

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