Hydrochloric Acid → HCID 59455657, Verbindung

HRID 1920177Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1920177
[Si]([O:8][C@@H:9]1[CH2:14][C@@H:13]([F:15])[CH2:12][NH:11][CH2:10]1)(C(C)(C)C)(C)C.Cl.[CH:17]([OH:20])([CH3:19])C.[CH3:21][OH:22]>>[F:15][C@@H:13]1[CH2:14][C@@H:9]([OH:8])[CH2:10][N:11]([C:21]([O:20][CH2:17][C:19]2[CH:10]=[CH:9][CH:14]=[CH:13][CH:12]=2)=[O:22])[CH2:12]1

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3776IsopropanolHCID 59455637(3R,5R)-3-(tert-butyldimethylsilyloxy)-5-fluoropiperidine

Produkt 1

HCID 59455657HCID 59455657, VerbindungAusbeute 94 %

Versuchsvorschrift

To a solution of (3R,5R)-3-(tert-butyldimethylsilyloxy)-5-fluoropiperidine (1 eq) in 30 mL of methanol was added 3.8M HCl in isopropanol (4 eq). The reaction mixture was allowed to stand at room temperature for 3 hours at which point it was concentrated under reduced pressure. The resulting residue was diluted with 120 mL of EtOAc, washed with sat. aq. sodium bicarbonate, brine, then dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The crude residue was purified by flash chromatography (EtOAc:hexanes=2:1) to give (3R,5R)-benzyl 3-fluoro-5-hydroxypiperidine-1-carboxylate, (94%). LC/MS (m/z): 254.2 (MH+).

Aufarbeitung

  1. concentrationwas concentrated under reduced pressure
  2. additionThe resulting residue was diluted with 120 mL of EtOAc
  3. washwashed with sat. aq. sodium bicarbonate, brine
  4. dry with materialdried over anhydrous MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customThe crude residue was purified by flash chromatography (EtOAc:hexanes=2:1)

Quellen und Nachweise

ORD-Eintrag
ord-7a5c5cc424f24bba9da7b6c0c331904e
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08168794B2

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