Methylamine → N-methyl benzothiophene-2-carboxamide

HRID 1921020

Reaktionsgleichung

Reaktionsgleichung von HRID 1921020
[CH3:1][NH2:2].[S:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]=[C:4]1[C:12](Cl)=[O:13]>C1COCC1>[CH3:1][NH:2][C:12]([C:4]1[S:3][C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]=1)=[O:13]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 142384Benzo[b]thiophene-2-carbonyl Chloride

Produkt 1

HCID 22593821N-methyl benzothiophene-2-carboxamideAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel3×

Versuchsvorschrift

To a stirred solution of 2.0 M methylamine in THF (60 mL) and THF (60 mL) was added dropwise at 0° C. a solution of benzothiophene-2-carbonyl chloride (10.8 g, 55 mmole) in THF (50 mL) over 15 minutes. After the addition the reaction was allowed to warm to RT then was concentrated under vacuum. Trituration with a cold solution of 4:1 H2O/methanol (50 mL), filtration, and drying under vacuum gave the title compound (10.35 g, 98%) as a white solid: MS (ES) m/e 191.9 (M+H)+.

Aufarbeitung

  1. additionAfter the addition the reaction
  2. concentrationthen was concentrated under vacuum
  3. filtrationTrituration with a cold solution of 4:1 H2O/methanol (50 mL), filtration
  4. customdrying under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-47d206de047e4ee68e496aeaa0acb160
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08173646B2

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