2-Chlorobenzylamine → 2-(2-Chloro-benzylamino)-benzooxazol-6-ol

HRID 1922195Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1922195
Cl[C:2]1[O:3][C:4]2[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][NH2:16]>CN1C(=O)CCC1.C(OCC)(=O)C>[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][NH:16][C:2]1[O:3][C:4]2[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:5]=2[N:6]=1

Komponenten

5

Edukt 2

HCID 666482-ChlorobenzylamineHCID 234412462-Chloro-1,3-benzoxazol-6-OL

Produkt 1

HCID 577253862-(2-Chloro-benzylamino)-benzooxazol-6-ol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8857Ethyl AcetateLösungsmittelHCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Versuchsvorschrift

2-Chloro-benzooxazol-6-ol (1 eq) and 2-chloro-benzylamine (2 eq) was dissolved in NMP. Using a Personal Chemistry microwave system, the mixture was reacted at 180° C. for six minutes. The crude reaction mixture was diluted with ethyl acetate and washed once with brine and once with 1N HCl, or washed twice with brine, depending on the amine used. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated. This material was purified by silica gel column using hexane and ethyl acetate. MH+=275.1.

Aufarbeitung

  1. customthe mixture was reacted at 180° C. for six minutes
  2. customThe crude reaction mixture
  3. washwashed once with brine and once with 1N HCl
  4. washwashed twice with brine
  5. dry with materialThe organic layer was dried with anhydrous sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customThis material was purified by silica gel column

Quellen und Nachweise

ORD-Eintrag
ord-c3dbcecbbb72402dafc5054673158991
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08173689B2

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