HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
N-methyl-4-(2-(methylsulfinyl)benzo[d]oxazol-6-yloxy)picolinamide → 4-{2-[1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-ethylamino]-benzooxazol-6-yloxy}-pyridine-2-carboxylic acid methylamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | N-methyl-4-(2-(methylsulfinyl)benzo[d]oxazol-6-yloxy)picolinamide | HCID 57725414 | — |
| Edukt | 1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-ethylamine | HCID 57725501 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 4-{2-[1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-ethylamino]-benzooxazol-6-yloxy}-pyridine-2-carboxylic acid methylamide | HCID 57725579 | — |
Reaktionsschritte
To a solution of 1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-ethylamine (3 eq) in THF was added 4-(2-methanesulfinyl-benzooxazol-6-yloxy)-pyridine-2-carboxylic acid methylamide (1 eq). This was stirred at room temperature for 8 hours, concentrated and the residue was purified by preparatory reverse phase HPLC. MH+=447.1.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08173689B2 |
| Quelldatensatz | uspto-grants-2012_05 |
| ORD ID | ord-8436d1ece2474fd08d21352ee65514bf |
| Quellennotiz | uspto-grants-2012_05 |