1-(Cyclopropylmethyl)piperazine → 4-(8-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine

https://huagongshe.com/reaction/1923027

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-(Cyclopropylmethyl)piperazine	HCID 965875	—
Edukt	4-(8-(bromomethyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine	HCID 59605812	—
Produkt	4-(8-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine	HCID 59605710	—

Reaktionsschritte

4-(8-(bromomethyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine (50 mg) was reacted with 1-(cyclopropylmethyl)piperazine via General Procedure E to give 23.5 mg of 277 following reverse phase purification. MS (Q1) 502.3 (M)+

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08173650B2
Quelldatensatz	uspto-grants-2012_05
ORD ID	ord-5b19a809e15d45eba777766f48717173
Quellennotiz	uspto-grants-2012_05