HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Oxa-8-azaspiro(4.5)decane → 8-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)-1-oxa-8-azaspiro[4.5]decane
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Oxa-8-azaspiro(4.5)decane | HCID 21934982 | — |
| Edukt | 4-(8-(bromomethyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine | HCID 59605812 | — |
| Produkt | 8-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)-1-oxa-8-azaspiro[4.5]decane | HCID 59605207 | — |
Reaktionsschritte
Alternatively, following General Procedure E for Displacement of alkyl bromide with amines, 4-(8-(bromomethyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine and 1-oxa-8-azaspiro[4.5]decane were reacted to give 370.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08173650B2 |
| Quelldatensatz | uspto-grants-2012_05 |
| ORD ID | ord-7340cf481dca4088884ffdcb23713b74 |
| Quellennotiz | uspto-grants-2012_05 |