HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Methylbenzimidazole → 5-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)-2-oxa-5-azabicyclo[2.2.1]heptane
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Methylbenzimidazole | HCID 11984 | — |
| Edukt | 2-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-5-oxa-2-aza-bicyclo[2.2.1]heptane | HCID 86648262 | — |
| Produkt | 5-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)-2-oxa-5-azabicyclo[2.2.1]heptane | HCID 59605324 | — |
Reaktionsschritte
Following General Procedure I for Buchwald coupling, 2-methylbenzimidazole and 2-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-5-oxa-2-aza-bicyclo[2.2.1]heptane were reacted to give 384. LCMS m/z: 461.2 (MH+)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08173650B2 |
| Quelldatensatz | uspto-grants-2012_05 |
| ORD ID | ord-80634d5c09c34dc5b32e3e3876d3a713 |
| Quellennotiz | uspto-grants-2012_05 |