4-Carboxychalcone → HCID 22251491, Verbindung

HRID 1923465Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1923465
[O:1]=[C:2]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH:3]=[CH:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1>[Ni].C(O)C>[O:1]=[C:2]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:3][CH2:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1

Komponenten

4

Edukt 1

HCID 39957814-Carboxychalcone

Produkt 1

HCID 22251491HCID 22251491, VerbindungAusbeute 59,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

4-(3-Oxo-3-phenyl-propenyl)-benzoic acid (7.64 g, 30 mmol) is combined with Raney nickel (2 g) in ethanol (140 mL). The mixture is hydrogenated at room temperature and 50 psi for 1.5 h. The reaction is filtered evaporated in vacuo. The resulting residue is recrystallized from ethyl acetate to obtain 4.57 g (59%) of the titled compound. m.p.=145-147° C.; Anal. Calcd for C16H14O3: C, 75.58; H, 5.55. Found: C, 75.60; H, 5.32.

Aufarbeitung

  1. customis hydrogenated at room temperature
  2. filtrationThe reaction is filtered
  3. customevaporated in vacuo
  4. customThe resulting residue is recrystallized from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-d8ef56805cad48769ca5617b918e30b8
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08178528B2

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