L-Alaninol → 2-[2-(3-Butyl-5-methyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid ((S)-2-hydroxy-1-methyl-ethyl)-amide
Reaktionsgleichung
CO[C:3]([C:5]1[S:9][C:8]([CH2:10][CH2:11][C:12]2[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[N:14][O:15][C:16]=2[CH3:17])=[N:7][CH:6]=1)=[O:4].[NH2:22][C@H:23]([CH2:25][OH:26])[CH3:24]>>[OH:26][CH2:25][C@@H:23]([NH:22][C:3]([C:5]1[S:9][C:8]([CH2:10][CH2:11][C:12]2[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[N:14][O:15][C:16]=2[CH3:17])=[N:7][CH:6]=1)=[O:4])[CH3:24]Komponenten
3
Versuchsvorschrift
As described for example 58, 2-[2-(3-butyl-5-methyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid methyl ester (90 mg, 0.29 mmol) was converted, using L-alaninol instead of rac-2-amino-1-propanol, to the title compound (50 mg, 81%) which was obtained as a colourless oil. MS: m/e=352.4 [M+H]+.
Quellen und Nachweise
- ORD-Eintrag
- ord-af0cf9cbf3a644fdafef0434b6cd9130
- Quelldatensatz
- uspto-grants-2012_05