Potassium Carbonate → 4H,5H,6H-thieno[2,3-c]pyrrol-6-one

HRID 1924969Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1924969
C[O:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[CH2:10][NH2:11])=O.C([O-])([O-])=O.[K+].[K+]>CO.CCO>[S:6]1[C:5]2[C:3](=[O:2])[NH:11][CH2:10][C:9]=2[CH:8]=[CH:7]1

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 53419606Methyl 3-(aminomethyl)thiophene-2-carboxylate

Produkt 1

HCID 205428054H,5H,6H-thieno[2,3-c]pyrrol-6-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 18681192Ethanol, mixt. with methanolLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a solution of 3-aminomethyl-thiophene-2-carboxylic acid methyl ester (0.82 g, 4.79 mmol) in 1:1 MeOH-EtOH (125 mL), is added K2CO3 (0.66 g, 4.79 mmol) and the mixture is stirred at 90° C. for 5 hours. The solvent is removed in vacuo and the residue purified by silica gel column chromatography eluting with 97:3 DCM:MeOH. The title compound is isolated (0.365 g, 55%).

Aufarbeitung

  1. customThe solvent is removed in vacuo
  2. customthe residue purified by silica gel column chromatography
  3. washeluting with 97:3 DCM

Quellen und Nachweise

ORD-Eintrag
ord-5ae8e46379d240868d75df4c096710e6
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08178530B2

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