4-Pentyn-1-ol → 5-[5-Amino-6-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)pyrimidin-4-yl]pent-4-yn-1-ol
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]([NH:17][C:18]2[C:23]([NH2:24])=[C:22](I)[N:21]=[CH:20][N:19]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=1.[CH2:26]([OH:31])[CH2:27][CH2:28][C:29]#[CH:30]>C(#N)C.C(N(CC)CC)C.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Cu]I>[NH2:24][C:23]1[C:22]([C:30]#[C:29][CH2:28][CH2:27][CH2:26][OH:31])=[N:21][CH:20]=[N:19][C:18]=1[NH:17][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=2)=[C:2]([Cl:1])[CH:3]=1Komponenten
6
