Hydrochloric Acid → 6-{[6-(4-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid

HRID 1926973Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1926973
[OH-].[Na+].C[O:4][C:5](=[O:36])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[C:13]2[C:20]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)=[C:19]([C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=3)[O:18][C:14]=2[N:15]=[CH:16][N:17]=1.Cl>O1CCOCC1>[F:35][C:32]1[CH:33]=[CH:34][C:29]([C:19]2[O:18][C:14]3[N:15]=[CH:16][N:17]=[C:12]([NH:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][C:5]([OH:36])=[O:4])[C:13]=3[C:20]=2[C:21]2[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=2)=[CH:30][CH:31]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 580169116-{[6-(4-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid methyl ester

Produkt 1

HCID 580168856-{[6-(4-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Add 1 ml 1 N sodium hydroxide solution to a solution of 169 mg (0.37 mmol) 6-{[6-(4-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid methyl ester in 5 ml dioxan and stir for 16 h at RT. After adding 3 ml 1 N hydrochloric acid, concentrate the reaction solution by vacuum evaporation. Mix the residue with diethyl ether, filter, and dry under vacuum. 165 mg (99% of theor.) of the desired product is obtained.

Aufarbeitung

  1. concentrationconcentrate the reaction solution
  2. customby vacuum evaporation
  3. additionMix the residue with diethyl ether
  4. filtrationfilter
  5. customdry under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-0645248e454143a79e6cc0f5339c0703
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08183246B2

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