3-Sulfamoylbenzoic acid → HCID 57468850, Verbindung
Reaktionsgleichung
[OH:1][NH:2][C:3]([C:5]1[N:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[N:6]=1)=[NH:4].[S:25]([C:29]1[CH:30]=[C:31]([CH:35]=[CH:36][CH:37]=1)[C:32](O)=O)(=[O:28])(=[O:27])[NH2:26]>>[F:14][C:11]([F:12])([F:13])[C:9]1[CH:8]=[C:7]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:17][CH:16]=2)[N:6]=[C:5]([C:3]2[N:4]=[C:32]([C:31]3[CH:30]=[C:29]([S:25]([NH2:26])(=[O:28])=[O:27])[CH:37]=[CH:36][CH:35]=3)[O:1][N:2]=2)[N:10]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared from N-hydroxy-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-carboxamidine (example C.2) (0.176 g, 0.5 mmol) and commercially available 3-sulfamoyl-benzoic acid (0.1 g, 0.5 mmol) according to the general procedure V. Obtained as an off-white solid (0.11 g, 42%). MS (ISN) 514.1 [(M−H)−]; mp 205° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-90ee9b7164794db291b7538fb1e00914
- Quelldatensatz
- uspto-grants-2012_05