6-Aminonicotinic acid → HCID 60209354, Verbindung
Reaktionsgleichung
[OH:1][NH:2][C:3]([C:5]1[N:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[N:6]=1)=[NH:4].[NH2:25][C:26]1[CH:34]=[CH:33][C:29]([C:30](O)=O)=[CH:28][N:27]=1>>[F:14][C:11]([F:12])([F:13])[C:9]1[CH:8]=[C:7]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:17][CH:16]=2)[N:6]=[C:5]([C:3]2[N:4]=[C:30]([C:29]3[CH:33]=[CH:34][C:26]([NH2:25])=[N:27][CH:28]=3)[O:1][N:2]=2)[N:10]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared from N-hydroxy-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-carboxamidine (example C.2) (0.176 g, 0.5 mmol) and commercially available 6-amino-nicotinic acid (0.07 g, 0.5 mmol) according to the general procedure V. Obtained as an off-white solid (0.055 g, 24%). MS (ISP) 453.1 [(M+H)+]; mp 205° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-c97d044b78f74d47b2dbb462b316f689
- Quelldatensatz
- uspto-grants-2012_05