Methylamine → Aminotetrahydrocyclopenta[b]indole

HRID 1928575

Reaktionsgleichung

Reaktionsgleichung von HRID 1928575
[CH2:1]1[C:12]2[CH:4]([N:5]=[C:6]3[C:11]=2[CH:10]=[CH:9][CH:8]=[CH:7]3)[CH2:3][CH2:2]1.C[NH2:14]>>[NH2:14][CH:1]1[C:12]2[CH:4]([N:5]=[C:6]3[C:11]=2[CH:10]=[CH:9][CH:8]=[CH:7]3)[CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 6329MethylamineHCID 66869719Tetrahydrocyclopent(b)indole

Produkt 1

HCID 66933239Aminotetrahydrocyclopenta[b]indole

Versuchsvorschrift

In Scheme 2, Step A, the phthalimide group of the tetrahydrocyclopenta[b]indole of formula (2) is cleaved with methylamine to provide an aminotetrahydrocyclopenta[b]indole of formula (3). Preferred conditions use a solvent such as ethanol at a temperature of about 0 to 35° C., for 3 to 24 hours. The resulting by-product is removed by making the pH alkaline and filtering the resultant precipitate. The product is isolated from the filtrate by precipitation with water and 10% NaOH.

Quellen und Nachweise

ORD-Eintrag
ord-adfb3cd9cc624b0c974098d072d26038
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08183388B2

Verknüpfte Notizen

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