Hydrochloric Acid → Hexanamide, 3-amino-N-cyclopropyl-2-hydroxy-, hydrochloride (1:1), (2S,3S)-
Reaktionsgleichung
[ClH:1].[CH:2]1([NH:5][C:6](=[O:21])[C@@H:7]([OH:20])[C@@H:8]([NH:12]C(OC(C)(C)C)=O)[CH2:9][CH2:10][CH3:11])[CH2:4][CH2:3]1>O1CCOCC1>[ClH:1].[CH:2]1([NH:5][C:6](=[O:21])[C@@H:7]([OH:20])[C@@H:8]([NH2:12])[CH2:9][CH2:10][CH3:11])[CH2:4][CH2:3]1Komponenten
4
Versuchsvorschrift
To a 4 M 1,4-dioxane solution (60 mL) of hydrogen chloride, (2S,3S)—N-cyclopropyl-3-(t-butoxycarbonyl)amino-2-hydroxyhexanoic acid amide (4.5 g) was added. A solid of the product aggregated to form a lump after about 5 minutes, and the flowability of the reaction liquid worsened. After the disappearance of the starting material, the solvent was evaporated away with an evaporator to obtain a concentrated product of (2S,3S)—N-cyclopropyl-3-amino-2-hydroxyhexanoic acid amide hydrochloride (chemical purity: 89.8 area %).