5-bromo-2-fluoro-N-methoxy-N-methylbenzamide → (5-Bromo-2-fluorophenyl)(cyclopropyl)methanone
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:14])=[C:6]([CH:13]=1)[C:7](N(OC)C)=[O:8].[CH:15]1([Mg]Br)[CH2:17][CH2:16]1>O1CCCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:14])=[C:6]([C:7]([CH:15]2[CH2:17][CH2:16]2)=[O:8])[CH:13]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
In an analogous manner to that described for the preparation of Building block C [a)], the reaction of 5-bromo-2-fluoro-N-methoxy-N-methyl-benzamide with cyclopropylmagnesium bromide in tetrahydrofuran yielded the title compound as a light yellow liquid; (HPLC 2.783 min 100%). Mass (calculated) C10H8BrFO [243.074]; (found) [M+H]+=243, [M+2-H]+=245.
Aufarbeitung
- customIn an analogous manner to that described for the preparation of Building block C [a)],
Quellen und Nachweise
- ORD-Eintrag
- ord-b8d362aeb98c4869875bf1f61a674324
- Quelldatensatz
- uspto-grants-2012_05
- Patentnummer
- US08188079B2
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