Hydrochloric Acid → 2-(4'-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)-2,2'-difluorobiphenyl-4-yl)acetic acid

HRID 1930128Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1930128
[OH-].[K+].[C:3]([C:6]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][C:21]([CH2:24][C:25]([O:27]C)=[O:26])=[CH:20][C:19]=3[F:29])=[C:14]([F:30])[CH:13]=2)[C:9]([CH3:31])=[N:8][C:7]=1[CH3:32])(=[O:5])[NH2:4].Cl>C(O)(C)(C)C>[C:3]([C:6]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][C:21]([CH2:24][C:25]([OH:27])=[O:26])=[CH:20][C:19]=3[F:29])=[C:14]([F:30])[CH:13]=2)[C:9]([CH3:31])=[N:8][C:7]=1[CH3:32])(=[O:5])[NH2:4]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 59627685Methyl 2-(4'-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2,2'-difluorobiphenyl-4-yl)acetate2×

Produkt 1

HCID 498472482-(4'-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)-2,2'-difluorobiphenyl-4-yl)acetic acidAusbeute 58,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6386tert-ButanolLösungsmittel

Reaktionsbedingungen

Temperatur
45 °C

Versuchsvorschrift

Powdered potassium hydroxide (96 mg, 1.71 mmol) was added in one portion to methyl 2-(4′-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2,2′-difluorobiphenyl-4-yl)acetate (Intermediate 6-1; 234 mg, 0.57 mmol) in tert-butanol (10 mL) at 45° C. The resulting solution was stirred at 45° C. for 30 minutes, 2M HCl (2 mL) was added and the mixture was evaporated to remove the organic solvent. The suspension was collected by filtration, washed with water (5 mL) and dried under vacuum to afford crude product. The crude product was purified by preparative HPLC (Waters XBridge Prep C18 OBD column, 5μ silica, 50 mm diameter, 150 mm length), using decreasingly polar mixtures of water (containing 0.1% formic acid) and MeCN as eluents. Fractions containing the desired compound were evaporated to dryness to afford 2-(4′-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2,2′-difluorobiphenyl-4-yl)acetic acid (132 mg, 58.5%) as a white solid.

Aufarbeitung

  1. customthe mixture was evaporated
  2. customto remove the organic solvent
  3. filtrationThe suspension was collected by filtration
  4. washwashed with water (5 mL)
  5. customdried under vacuum
  6. customto afford crude product
  7. customThe crude product was purified by preparative HPLC (Waters XBridge Prep C18 OBD column, 5μ silica, 50 mm diameter, 150 mm length)
  8. additionFractions containing the desired compound
  9. customwere evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-1b18896691504c6994f96b645f55b9b9
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08188092B2

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