Potassium Carbonate → 1-(2-(2-(3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-yl)ethyl)pyrrolidin-2-one

HRID 1930719Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1930719
O=[C:2]([CH:11]1[C:16](=O)[CH2:15][CH2:14][O:13][CH2:12]1)[CH2:3][CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][C:6]1=[O:10].[CH3:18][O:19][C:20]1[CH:21]=[C:22]([NH:32][C:33]([NH2:35])=[NH:34])[CH:23]=[CH:24][C:25]=1[N:26]1[CH:30]=[C:29]([CH3:31])[N:28]=[CH:27]1.C(=O)([O-])[O-].[K+].[K+]>CCO>[CH3:18][O:19][C:20]1[CH:21]=[C:22]([NH:32][C:33]2[N:35]=[C:2]([CH2:3][CH2:4][N:5]3[CH2:9][CH2:8][CH2:7][C:6]3=[O:10])[C:11]3[CH2:12][O:13][CH2:14][CH2:15][C:16]=3[N:34]=2)[CH:23]=[CH:24][C:25]=1[N:26]1[CH:30]=[C:29]([CH3:31])[N:28]=[CH:27]1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 59333778HCID 59333778, VerbindungHCID 178493227HCID 178493227, Verbindung

Produkt 1

HCID 593337661-(2-(2-(3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-yl)ethyl)pyrrolidin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

1-(3-oxo-3-(4-oxotetrahydro-2H-pyran-3-yl)propyl)pyrrolidin-2-one (202 mg, 0.84 mmol), 1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)guanidine (1 equiv.) and potassium carbonate (2 equiv.) were heated to 50° C. over night in EtOH (5 mL). The crude product was extracted into DCM and solvent was evaporated. The crude product was purified by flash chromatogaphy (0-100% EtOAc in heptanes) followed by prepHPLC to afford the titled compound.

Aufarbeitung

  1. extractionThe crude product was extracted into DCM and solvent
  2. customwas evaporated
  3. customThe crude product was purified by flash chromatogaphy (0-100% EtOAc in heptanes)

Quellen und Nachweise

ORD-Eintrag
ord-0dfd971067b4487081acab2d07b9b480
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08188101B2

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