Piperidine → HCID 59152239, Verbindung

HRID 1931403Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1931403
[O:1]=[C:2]1[O:6][C:5]([CH2:7][CH2:8][C:9]([OH:11])=O)=[N:4][N:3]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[B-](F)(F)(F)F.CCOC(C(C#N)=NOC(N(C)C)=[N+](C)C)=O.[NH:40]1[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1>CN(C=O)C>[O:11]=[C:9]([N:40]1[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1)[CH2:8][CH2:7][C:5]1[O:6][C:2](=[O:1])[N:3]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:4]=1

Komponenten

5

Edukt 3

HCID 8082PiperidineHCID 2733286O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 68536689HCID 68536689, Verbindung

Produkt 1

HCID 59152239HCID 59152239, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

50 mg (0.21 mmol) of 3-(5-oxo-4-phenyl-4,5-dihydro-[1,3,4]oxadiazol-2-yl)-propionic acid, 245 mg (2.13 mmol) of NEM and 77 mg (0.23 mmol) of TOTU were dissolved in 2 ml of DMF and stirred at room temperature for 15 min. 20 mg (0.23 mmol) of piperidine were added, and the reaction mixture was stirred at room temperature for 16 h. After evaporation, the product was purified by silica gel chromatography. Yield: 45 mg.

Aufarbeitung

  1. stirringthe reaction mixture was stirred at room temperature for 16 h
  2. customAfter evaporation
  3. customthe product was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-d604148a44ad456087b724ecefa82405
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08188291B2

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