Triethylamine → HCID 68537700, Verbindung

HRID 1931407Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1931407
[CH2:1]([O:3][C:4](=[O:13])[CH2:5][C:6]([CH3:12])([CH3:11])[C:7](=O)[CH2:8]Br)[CH3:2].[F:14][C:15]([F:26])([F:25])[C:16]1[CH:24]=[CH:23][C:19]([C:20]([NH2:22])=[S:21])=[CH:18][CH:17]=1.C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:13])[CH2:5][C:6]([CH3:12])([C:7]1[N:22]=[C:20]([C:19]2[CH:18]=[CH:17][C:16]([C:15]([F:25])([F:14])[F:26])=[CH:24][CH:23]=2)[S:21][CH:8]=1)[CH3:11])[CH3:2]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 2724583Ethyl 5-bromo-3,3-dimethyl-4-oxopentanoateHCID 27348234-(Trifluoromethyl)thiobenzamide

Produkt 1

HCID 68537700HCID 68537700, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

500 mg (1.99 mmol) of 5-bromo-3,3-dimethyl-4-oxo-pentanoic acid ethyl ester, 408.6 mg (1.99 mmol) of 4-trifluoromethyl-thiobenzamide and 403 mg (3.98 mmol) of triethylamine in 10 ml of toluene were stirred at 80° C. for 2 h. After evaporation, water and dichloromethane were added, the organic phase was separated, washed with water, dried, and evaporated. The product was purified by chromatography (silica gel, n-heptane/ethyl acetate 8:1). Yield: 498.5 mg.

Aufarbeitung

  1. customAfter evaporation, water and dichloromethane
  2. additionwere added
  3. customthe organic phase was separated
  4. washwashed with water
  5. customdried
  6. customevaporated
  7. customThe product was purified by chromatography (silica gel, n-heptane/ethyl acetate 8:1)

Quellen und Nachweise

ORD-Eintrag
ord-9c784b38cb46447dbea445840834b450
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08188291B2

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