Thionyl Chloride → 3-[6-(2-Fluoro-phenyl)-pyridin-3-yl]-propionyl chloride hydrochloride
Reaktionsgleichung
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([OH:18])=O)=[CH:10][CH:9]=1.S(Cl)([Cl:21])=O>>[ClH:21].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([Cl:21])=[O:18])=[CH:10][CH:9]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared in quantitative yield by boiling 3-[6-(2-fluoro-phenyl)-pyridin-3-yl]-propionic acid in thionyl chloride, followed by removal of the volatiles by coevaporating three times with toluene.
Aufarbeitung
- customfollowed by removal of the volatiles
Quellen und Nachweise
- ORD-Eintrag
- ord-a44ee74777e746109468df1306419541
- Quelldatensatz
- uspto-grants-2012_05
- Patentnummer
- US08188291B2
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